Download Protein Design: Methods and Applications by Neil Errington, Teuku Iqbalsyah, Andrew J. Doig (auth.), PDF

By Neil Errington, Teuku Iqbalsyah, Andrew J. Doig (auth.), Raphael Guerois, Manuela López de la Paz (eds.)

Recent significant advances in our realizing of modulating protein services has resulted in the improvement of recent tools and algorithms to foretell and decipher how amino acid sequences form 3-dimensional buildings. Protein layout: tools and purposes provides the main updated protein layout and engineering ideas in order that readers can adopt their very own initiatives with a greatest probability of success.
The authors current built-in computational methods that require quite a few levels of computational complexity, and the foremost accomplishments which were completed within the layout and structural characterization of helical peptides and proteins. different issues of debate comprise: layout of structural effortless motifs, complete proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors.
Authoritative and state of the art, Protein layout: equipment and purposes can be of significant curiosity to protein scientists, biochemists, and all experimentalists picking the tactic such a lot adaptable for his or her layout problem.

Show description

Read Online or Download Protein Design: Methods and Applications PDF

Best biotechnology books

Environmental Biotechnology: Theory and Application

Biotechnology has come to play an more and more vital function in lots of points of way of life. as soon as a pricey and principally unexpected choice, it has now turn into a pragmatic replacement to many tested ways for production, land remediation, pollutants keep an eye on and waste administration. the appliance of biologically-engineered recommendations to environmental difficulties has turn into way more with ease appropriate in precept and biotechnology, normally, extra generally understood, yet there continues to be a few uncertainty among practitioners concerning how and the place the microscopic, useful point suits into the macroscopic, sensible functions.

RNA-Protein Interaction Protocols

End result of the very important organic significance of RNA and proteins functioning jointly inside a telephone, a protocol quantity describing experimental methods to review their interactions should still discover a domestic in lots of laboratories. RNA-Protein interplay Protocols, moment variation updates, enhances, and expands upon the preferred first version via supplying a suite of state of the art concepts built or subtle long ago few years in addition to tried-and-true equipment.

Genomics and Systems Biology of Mammalian Cell Culture

Transcriptome research, by means of Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam Lübbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome facts research for phone tradition methods, via Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian mobilephone platforms: common concerns, Modeling recommendations, and on hand instruments, via Ziomara P.

Modern Biopharmaceuticals: Recent Success Stories

This number of high-profile contributions presents a distinct perception into the improvement of novel, winning biopharmaceuticals. awesome authors, together with Nobel laureate Robert Huber in addition to favourite corporation researchers and CEOs, current worthwhile insider wisdom, restricting their scope to these techniques and advancements with confirmed strength for the biotechnology undefined.

Extra info for Protein Design: Methods and Applications

Example text

Viguera, A. , and Serrano, L. (1998) Elucidating the folding problem of α-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters. J. Mol. Biol. 284, 173–191. 54. Muñoz, V. and Serrano, L. (1994) Elucidating the folding problem of helical peptides using empirical parameters. Nat. Struct. Biol. 1, 399–409. 55. Muñoz, V. and L. Serrano, L. (1995) Elucidating the folding problem of helical peptides using empirical parameters. II. Helix macrodipole effects and rational modification of the helical content of natural peptides.

Acad. Sci. USA 90, 11332–11336. 14. , Feliciano, E. , and Nambiar, K. P. (1993) Stabilization of alphahelical structures in short peptides via end capping. Proc. Natl. Acad. Sci. USA 90, 838–842. 15. Dasgupta, S. and Bell, J. A. (1993) Design of helix ends. Amino acid preferences, hydrogen bonding and electrostatic interactions. Int. J. Pept. Prot. Res. 41, 499–511. 16. Harper, E. T. and Rose, G. D. (1993) Helix stop signals in proteins and peptides: the capping box. Biochemistry 32, 7605–7609.

Morozova-Roche, L. , Cochran, D. A. , Doig, A. , and Barron, L. D. (2000) Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme. J. Mol. Biol. 301, 553–563. 103. Barron, L. , Blanch, E. , and Bell, A. F. (2000) Solution structure and dynamics of biomolecules from Raman optical activity. Prog. Biophys. Mol. Biol. 73, 1–49. 26 Errington, Iqbalsyah, and Doig 104. Pace, C. N. and Scholtz, J. M. (1998) A helix propensity scale based on experimental studies of peptides and proteins.

Download PDF sample

Rated 4.48 of 5 – based on 13 votes