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By K. Lerner, B. Lerner

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When the immune system detects something as foreign, it sends white blood cells called T-lymphocytes to attack it. The immune system usually considers a transplanted organ as foreign and tries to destroy it. This is called rejection. A person who rejects his or her new organ can become very sick and can even die. When people start taking anti-rejection drugs, they take them in very high doses. After a few months, the risk of rejection goes down as the body gets used to the new organ. The patient can then take lower doses of the anti-rejection drugs.

Monoclonal antibodies to cytokine and various receptors important in arthritis have been developed and tested. Because the basis of the strategy is the recombination of two types of cells (the lymphocytes and the tumor cells), it is referred to as recombination therapy. The results have been encouraging. Assessment of the drugs in animals that develop conditions similar to human arthritis, and in clinical trials that actually test the drug in humans have indicated that the drugs are beneficial and, at least so far, acceptably safe.

Its side effects include loose stools (diarrhea), lower numbers of white blood cells, blood infection, and other kinds of infections. 6 Biotechnology: Changing Life Through Science ANTI-REJECTION DRUGS Souvenir Soils Several pharmaceutical companies encourage their employees to collect and bring back soil samples during their vacation travels. Anti-rejection drugs such as drugs cyclosporine and tacrolimus are made from fungi found in soils in different parts of the world. Development Doctors have been able to transplant an organ from one person to another since the early 1900s.

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