By FLOREY KLAUS
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Additional info for Analytical Profiles of Drug Substances, Vol. 8
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He had evidence for formation of another nitrogen containing derivative. This early investigation should give food for thought to those who believe that pro-drugs and pharmacokinetics are recent discoveries. 7. In 1911, NeuberglE6 detected small amounts of gentisic acid (2,5-dihydroxybenzoic acid) in the urine of dogs dosed with aspirin. The metabolism of aspirin is intertwined with that of salicylic acid, but I was unable to ascertain who first reported the metabolic formation of salicyluric acid, the major metabolite of both salicylic acid and aspirin, specifically after administration of aspirin.