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KLAUS FLOREY 46 199. V. H. Blythe, Drug Standards, 28, 5 (1960). 200. G. Pharm. 88 (1961). 201. G . R. A. Procknal, J. Pharm. , 54, 1719 (1965). 202. G. L. J. V. Griffiths, J. Pharm. , 23,. 534 (1971). 203. K. M. Haram, R. Norberg, S. Oie, Pharm. , 48, 610 (1973). 204. G. Levy and A. Yacobi, J. Clin. , 15, 525 (1975). 205. S. Goto, J. Nakashima, M. Tsuruta, H. Sato, T. A. 83, 152268~(1975). 206. C. gller, Am. J. Clin. , 17, 22 (1947). 207. J. E. J. Keenan, Pediatrics, 59, 55 (1977). 208. G. Levy and T A .

He had evidence for formation of another nitrogen containing derivative. This early investigation should give food for thought to those who believe that pro-drugs and pharmacokinetics are recent discoveries. 7. In 1911, NeuberglE6 detected small amounts of gentisic acid (2,5-dihydroxybenzoic acid) in the urine of dogs dosed with aspirin. The metabolism of aspirin is intertwined with that of salicylic acid, but I was unable to ascertain who first reported the metabolic formation of salicyluric acid, the major metabolite of both salicylic acid and aspirin, specifically after administration of aspirin.

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