Download AID for Immunoglobulin Diversity by Frederick W. Alt PDF

By Frederick W. Alt

Advances in Immunology, an extended confirmed and hugely revered serial, provides present advancements in addition to complete stories in immunology. Articles deal with the big variety of themes that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored through the most important scientists within the box, every one quantity presents updated details and instructions for destiny learn.

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J. Immunol. 154, 6624–6633. , and Honjo, T. (2002). Critical roles of activation‐induced cytidine deaminase in the homeostasis of gut flora. Science 298, 1424–1427. , Weill, J. , and Reynaud, C. A. (2002). AID‐dependent somatic hypermutation occurs as a DNA single‐ strand event in the BL2 cell line. Nat. Immunol. 3, 815–821. Fu, Y. , and Chaplin, D. D. (1998). B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin a‐dependent fashion. J. Exp. Med. 187, 1009–1018.

During repair of AID‐induced S region cleavage, UNG might be recruited into the complex via its WXXF motif. A Vpr‐like UNG‐interacting host protein may exist and contribute to CSR being associated with UNG, which may also interact with error‐prone DNA polymerases, 50 –30 exonucleases, and so on. DISCOVERY AND FUNCTION OF AID 21 problem with the system. When APOBEC1, a bona fide RNA editing enzyme, is overexpressed in E. , 2002). , 2004), the ability to make valid comparisons between the E. coli system and actual CSR and SHM in B cells is severely limited.

Chem. 283, 732–742. , Pomerantz, R. , and Duan, L. X. (1998). Diversity of HIV‐1 Vpr interactions involves usage of the WXXF motif of host cell proteins. J. Biol. Chem. 273, 8009–8016. , Scharff, M. , and Goodman, M. F. (2003). Activation‐induced cytidine deaminase deaminates deoxycytidine on single‐stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102–4107. , and Goodman, M. F. (2004). Biochemical analysis of hypermutational targeting by wild type and mutant activation‐induced cytidine deaminase.

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