By Stefan Guhlke (auth.), Jan Bucerius, Hojjat Ahmadzadehfar, Hans-Jürgen Biersack (eds.)
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that's commonplace for the imaging of myocardial perfusion, in addition to numerous malignant and benign illnesses. 99mTc-Sestamibi – medical purposes presents a close and informative evaluate of just about the entire oncologic and non-oncologic purposes of 99mTc-sestamibi SPECT, together with numerous fairly infrequent symptoms. assorted disease-related protocols for 99mTc-sestamibi SPECT are awarded, and for every illness a entire precis of the correct pathology and epidemiology is equipped. all through, there's a powerful emphasis at the sensible elements of use of this well known tracer, together with directions for the training of numerous commercially to be had tracer kits. scientific practitioners will locate this publication to be a useful advisor to the appliance and merits of 99mTc-sestamibi SPECT in either the inpatient and the outpatient setting.
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Extra info for 99mTc-Sestamibi: Clinical Applications
Ann ICRP 28:107–111 20. ICRP Publication 103 (2007) The 2007 Recommendations of the International Commission on Radiological Protection. Ann ICRP 37:2–4 21. ICRP Publication 106 (2008) Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. Ann ICRP 38:159–162 22. Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ (2007) Radiation dose to patients from cardiac diagnostic imaging. Circulation 116:1290–1305. 688101 23. Lassmann M, Biassoni L, Monsieurs M, Franzius C, Jacobs F (2007) The new EANM paediatric dosage card.
However, it is considered to be good radiopharmacy practice to ensure an injection with a radiopharmaceutical of 3 Preparation of Tc-99m-Sestamibi 29 the highest purity, safety, and efﬁcacy. The recommended radiochromatographic procedure for the determination of radiochemical purity of Tc-99m-sestamibi involves the use of an aluminum oxide-coated (Baker-ﬂex) plastic thin-layer chromatography plate with absolute ethanol as developing agent. 5 cm from the bottom of a dry plate and two drops of Tc-99msestamibi solution are added on top of the ethanol spot.
Similar results were published by the same group in 86 patients: pinhole images were obtained 15 min and 2–4 h after injection of Sestamibi. The addition of a routine correlative thyroid 99mTc-pertechnetate scan signiﬁcantly improved sensitivity so that the pinhole technique is recommended as a procedure of choice for parathyroid imaging. A lot of papers described some biological factors inﬂuencing Sestamibi parathyroid scintigraphy. Custodio et al.  studied patients with secondary hyperparathyroidism and have found that high Sestamibi scores were associated with high estimated gland weight, degree of cell proliferation, and presence of nodular hyperplasia.